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KMID : 0861120110150010029
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Korean Journal of Oriental Preventive Medicine
2011 Volume.15 No. 1 p.29 ~ p.36
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Hypoglycemic and hypolipidemic effects of Allium victorialis leaf extract in high fat diet supplied mice
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Ku Sae-Kwang
Chung In-Kwon
Cheon Woo-Hyun
Lee Young-Joon
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Abstract
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The hypoglycemic and hypolipidemic effects of Allium victorialis (AV) leaf methanol extract were evaluated in a high fat diet (HFD) supplied mice. Changes on the serum glucose, total cholesterol, triglyceride, low density lipoprotein and high density lipoprotein were examined. The effects were compared with those of a group given 250 mg/kg of metformin. After 91 days of a continuous HFD supply, the mice were showed marked hyperglycemia and hyperlipemia. However, these hyperglycemia and hyperlipemia induced by the HFD were inhibited by the AV extract treatment at the three different doses (62.5, 125 and 250 mg/kg). The results suggest that the AV methanol extract is beneficial for improving the diet-induced hyperlipidemia and hyperglycemia in humans.
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KEYWORD
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Allium victorialis, hypoglycemic effects, hypolipidemic effects, high fat diet, mouse
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